Countries finalize historic pandemic agreement after three years of negotiations

Two individuals celebrating the conclusion of a significant agreement at the World Health Organization (WHO) event, with WHO branding in the background.
WHO/Christopher Black. WHO Director-General Tedros Adhanom Ghebreyesus (right) and INB Co-Chair Anne-Claire Amprou of France (left) celebrate at the conclusion of negotiations in the early hours of 16 April 2025.

This article is published in association with United Nations.


In the early hours of Wednesday morning in Geneva, countries finalized a draft global agreement aimed at improving how the world prepares for and responds to pandemics, marking a historic step that will be submitted to the World Health Assembly in May for adoption.

Developed after over three years of negotiations under the auspices of the World Health Organization (WHO), the draft outlines a framework for strengthening international collaboration, equity and resilience in the face of future global health threats.

“The nations of the world made history in Geneva today,” said WHO Director-General Tedros Adhanom Ghebreyesus.

“In reaching consensus on the Pandemic Agreement, not only did they put in place a generational accord to make the world safer. They have also demonstrated that multilateralism is alive and well and that in our divided world – nations can still work together to find common ground and a shared response to shared threats.”

‘One health’ approach

Negotiations began in December 2021 at the height of the COVID-19 pandemic, when WHO member States agreed on the urgent need for a legally binding international instrument and established the Intergovernmental Negotiating Body (INB).

The process involved 13 formal rounds of negotiations, many of which were extended into the early hours, culminating in Wednesday’s consensus after a final overnight session.

Key elements of the proposed agreement include a commitment to a “One Health” approach to pandemic prevention, stronger national health systems, setting up a coordinating financial mechanism, and creating a globally coordinated supply chain and logistics network for health emergencies.

The draft also proposes a new pathogen access and benefit-sharing system, increased support for technology and knowledge transfer as well as capacity-building, and outlines a skilled, trained and multidisciplinary national and global health emergency workforce.

National sovereignty upheld

The text further affirms national sovereignty in public health decisions. It states explicitly that nothing in the agreement gives WHO the authority to mandate health measures such as lockdowns, vaccination campaigns, or border closures.

The draft will now be submitted for consideration to the 78th World Health Assembly – UN’s highest forum for global health – set to begin on 19 May. If adopted, it will be subject to ratification by individual nations.

According to media reports, the United States did not participate in the final round of negotiations, following its January announcement to withdraw from the global health body, and would not be bound by the pact.

https://news.un.org/en/media/oembed?url=https%3A//www.youtube.com/watch%3Fv%3DEsCAsxPoc1Q&max_width=0&max_height=0&hash=e0DVhLsQuG4SfsywKFBhHGmNbkX7ZiG5xdzJ6NrQP4UFive Facts: Proposed pandemic agreement.

A breakthrough for health equity

Speaking at the conclusion of the meeting, WHO Director-General Tedros praised the negotiating teams and the INB leadership for their perseverance and shared purpose.

“This achievement is not just a diplomatic success,” he said. “It reflects your resilience, unity and unwavering commitment to the health and wellbeing of people everywhere.”

INB Co-Chair Precious Matsoso of South Africa called the outcome a breakthrough for health equity.

“The negotiations, at times, have been difficult and protracted. But this monumental effort has been sustained by the shared understanding that viruses do not respect borders – that no one is safe from pandemics until everyone is safe,” she said.

Fellow Co-Chair Anne-Claire Amprou of France added that the agreement lays the foundation for a stronger, more equitable global health security architecture.

“This is a historic agreement for health security, equity and international solidarity,” she said.

Learning from COVID-19, looking to the future

The agreement emerges in the aftermath of the COVID-19 pandemic, which exposed critical vulnerabilities in global health systems and stark inequalities in access to diagnostics, treatments, and vaccines. The virus claimed nearly seven million lives worldwide, severely disrupted economies, and overwhelmed healthcare services across the globe.

At the same time, the pandemic triggered the largest vaccination campaign in history, with over 13.3 billion doses administered globally by April 2023.

Looking ahead, Tedros emphasised the agreement’s long-term significance.

“The importance of this agreement goes beyond our current challenges,” he said.

“It is vital for future generations – for our children and grandchildren. By building a strong framework for pandemic preparedness and response, we ensure they inherit a safer and healthier world.”


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