European Health Union: Commission establishes portfolio of 10 most promising treatments for COVID-19

(Credit: Unsplash)

This article is brought to you in association with the European Commission.

Delivering on a key action from the EU Strategy on COVID-19 Therapeutics, the Commission is today establishing a portfolio of 10 potential COVID-19 therapeutics. The list established is based on independent scientific advice, and focuses on COVID-19 treatment candidates that are likely to be authorised and therefore available on the European market soon. These therapeutics will bring treatment to patients across the EU as fast as possible provided that their safety and effectiveness has been confirmed by the European Medicines Agency.

Vaccination against COVID-19 offers the best preventive protection against infection, severe disease, loss of life and long-term consequences of illness. While vaccination offers the best way to end the pandemic and get back to normal life, in parallel, we are ensuring that the COVID-19 therapeutics are available to treat those who are infected.

Vice-President for Promoting our European Way of Life, Margaritis Schinas said: “As we continue to face the challenge of COVID-19, it is important to shield ourselves in addition to vaccination. The establishment of 10 COVID-19 therapeutics will ensure that citizens receive the most promising treatments against the virus.”

Commissioner for Health and Food Safety, Stella Kyriakides, said: “Vaccination is the only tool to prevent COVID hospitalisations and deaths, and as such, it is the only way out of this pandemic. In the meantime however, COVID-19 patients do need safe and effective treatments to fight the infection, improve their prospect of a swift recovery, reduce hospitalisations and most importantly, to prevent loss of life. We have already signed four joint procurement contracts for different COVID-19 treatments and we stand ready to negotiate more. Our goal is to authorise at least three therapeutics in the coming weeks and possibly two more by the end of the year and help Member States gain access to them as soon as possible.”

The EU Strategy on COVID-19 Therapeutics is an integral element of the work to build a strong European Health Union, and is modelled on the successful EU Vaccines Strategy.

A group of independent scientific experts has screened 82 therapeutic candidates in late stage clinical development and identified 10 candidates as the most promising for the EU portfolio of COVID-19 treatments, taking into account that different types of products are needed for different patient populations and at different stages and severity of the disease. The list of ten is divided in three categories of treatments and will continue to evolve as new scientific evidence emerges:

  • Antiviral monoclonal antibodies that are most efficacious in the earliest stages of infection:       
    • Ronapreve, a combination of two monocolonal antibodies casirivimab and imdevimab from Regeneron Pharmaceuticals and Roche.
    • Xevudy (sotrovimab) from Vir Biotechnology and GlaxoSmithKline.
    • Evusheld, a combination of two monoclonal antibodies tixagevimab and cilgavimab from AstraZeneca.
  • Oral antivirals for use as quickly as possible after the infection:
    • Molnupiravir from Ridgeback Biotherapeutics and MSD.
    • PF-07321332 from Pfizer.
    • AT-527 from Atea Pharmaceuticals and Roche.
  • Immunomodulators to treat hospitalised patients:  
    • Actemra (tocilizumab) from Roche Holding.
    • Kineret (anakinra) from Swedish Orphan Biovitrum.
    • Olumiant (baricitinib) from Eli Lilly.
    • Lenzimulab from Humaningen.

Next Steps

Six of the selected therapeutics are already under rolling review or have applied for marketing authorisation to the European Medicines Agency. They could receive authorisation soon, provided the final data demonstrate their quality, safety, and efficacy.

The selection of the 10 candidates is independent from and does not replace the scientific assessment by the European Medicines Agency or the authorisation of the medicines by the European Commission. A selected product may not be authorised, if the available scientific evidence does not meet the regulatory requirements.

The four other candidates on the list all received scientific advice from EMA, and once enough clinical data is collected, further rolling reviews can start.

As announced in the Therapeutics Strategy, an innovation booster will support those therapeutics at earlier stages of development.

The Health Emergency Preparedness and Response Authority (HERA) will set up an interactive mapping platform for promising therapeutics. A call for tender to design the platform has been launched.

In November, a pan-European matchmaking event for therapeutics industrial production will be organised to help accelerate the development of new and repurposed medicines for COVID-19 therapeutics and mobilise the EU’s pharmaceutical manufacturing capacity.


The EU strategy on COVID-19 therapeutics complements the EU Vaccines Strategy, which remains the EU’s primary tool for ending the pandemic by preventing and reducing transmission of cases, as well as hospitalisation rates and deaths caused by the disease.

The Therapeutics Strategy aims to build a broad portfolio of COVID-19 therapeutics with the goal of having three to five new therapeutics available by the end of the year. It covers the full lifecycle of medicines from research, development, selection of promising candidates, fast regulatory approval, manufacturing and deployment to final use. A first list of five promising therapeutics was published in June 2021.

The Strategy forms part of a strong European Health Union, using a coordinated EU approach to better protect the health of our citizens, equip the EU and its Member States to better prevent and address future pandemics, and improve resilience of Europe’s health systems.

the sting Milestones

Featured Stings

Stopping antimicrobial resistance would cost just USD 2 per person a year

Can we feed everyone without unleashing disaster? Read on

These campaigners want to give a quarter of the UK back to nature

How to build a more resilient and inclusive global system

Lebanon: UN rights office calls for de-escalation of protest violence

Here’s how companies can make sure they are blockchain-ready

Why the financial scandals multiply?

JADE Generations Club: Connecting perspectives, changing Europe.

At global health forum, UN officials call for strong, people-focused health systems

To entrepreneurship and beyond!

My ‘’cultural’’ contacts with China

‘We are nowhere closer’ to Israeli-Palestinian peace deal, than a year ago, Security Council hears

‘Rare but devastating’ tsunamis underscore need for better preparation, UN chief urges on World Day

‘Regional security and integration’ in Central Africa under threat, Security Council warned

‘Spectre of poverty’ hangs over tribes and indigenous groups: UN labour agency

Recovery and Resilience Facility: Romania submits official recovery and resilience plan

Artificial intelligence: Commission takes forward its work on ethics guidelines

Industrial policy: recommendations to support Europe’s leadership in six strategic business areas

The ocean is teeming with microplastic – a million times more than we thought, suggests new research

Can Obama attract Iran close to the US sphere of influence?

Bring killers of journalists to justice: UN agency seeks media partners for new campaign

Regulate social media platforms to defend democracy, MEPs say

Canada has the most comprehensive and elaborate migration system, but some challenges remain

G20 LIVE: World Leaders in Turkey for G20 Summit. Global Economy will be discussed in Antalya

These countries are the most optimistic about economic recovery from the pandemic

Last-chance Commission: Why Juncker promised investments of €300 billion?

COP25: Developing nation’s strike hard

Ireland’s planning to make its Emerald Isle even greener

Peer-to-peer learning: a way to develop medical students’ trainings

ISIL continues to pose a ‘serious challenge’ worldwide – UN counter-terror chief

Biodiversity: MEPs demand binding targets to protect wildlife and people

Leaders need hard data to make the hard decisions about sustainability

Nicaragua ‘crisis’ still cause for concern amid murder, torture allegations: Bachelet

Trump: Hostile to Europe, voids Tillerson’s “ironclad” ally pledge

Businesses, governments and consumers to implement a more climate-friendly approach to #BeatPlasticPollution on World Environment Day 2018

Right2Water initiative: Is the Commission ready to listen to citizens?

Trump’s withdrawal from the Paris climate deal is bad for US business. Here’s why.

3 natural mysteries that could be explained by quantum physics

The winds of change: 5 charts on the future of offshore power

Millions of Bangladeshi children at risk from climate crisis, warns UNICEF

COVID-19 and the importance of scientific credibility in decreasing the number of cases

Antitrust: Commission opens investigation into possible anti-competitive conduct of Amazon

Plastic is a global problem. It’s also a global opportunity

NASA is recruiting new astronauts – this is what it takes to apply

Why it’s time to celebrate migrants

Fighting forest fires in Europe – how it works

The Pegasus Project awarded the 2021 Daphne Caruana Galizia Prize for Journalism

Detecting online child sexual abuse requires strong safeguards

Sexual reproductive health rights SRHR and ending HIV: can one be achieved without the other?

Greenhouse gas emissions have already peaked in 30 major cities

Transparency, EU values, and pluralism: new rules for European political parties

Central Asia bloc has important role in ‘peace, stability and prosperity’ beyond region, says Deputy UN chief

Greater transparency, fairer prices for medicines ‘a global human rights issue’, says UN health agency

It’s time to end our ‘separate but unequal’ approach to mental health

How smart tech helps cities fight terrorism and crime

EU and Mercosur reach agreement on trade

UN committed to helping Haiti build better future, says Guterres, marking 10-year anniversary of devastating earthquake

Antitrust: Commission sends Statement of Objections to O2 CZ, CETIN and T-Mobile CZ for their network sharing agreement

5 things to know about the exploding world of pro gaming

World Food Programme accesses Yemeni frontline district for first time since conflict began

UN chief calls for ‘immediate end’ to escalation of fighting in southwestern Syria, as thousands are displaced

The world’s food waste problem is bigger than we thought – here’s what we can do about it

A Sting Exclusive: “Seize the opportunity offered by Africa’s continental free trade area”, written by the Director General of UNIDO

More Stings?


  1. Typo needs correction to Lenzilumab from Humanigen

Speak your Mind Here

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: