Understanding the ‘second brain’ in your gut

(Credit: Unsplash)

This article is brought to you thanks to the collaboration of The European Sting with the World Economic Forum.

Author: Sean Fleming, Senior Writer, Formative Content


  • The enteric nervous system can operate on its own without being directed by the central nervous system.
  • It is there to keep your gut working, help absorb nutrients and keep out harmful agents.
  • A new study offers fresh insights into how it works.

Going straight to the top of the list of sentences you probably weren’t expecting to read – you have a ‘second brain’ in your gut.

It’s known as the enteric nervous system (ENS) and in evolutionary terms has probably been around much longer than the brain you’re currently using to read and understand these words.

Research into the ENS published in August 2021 offers new insights into how it works and the extent to which the ENS is similar to other neural networks throughout the human body, including those found in the brain and spinal cord.

But before we get to that – what exactly is the ENS, and what does it do?

What is the enteric nervous system?

The ENS is a web of neurons found in the wall of the gastrointestinal system.

It stretches from the bottom of the tube that connects the throat to the stomach, the esophagus, through to the rectum.

Studies estimate that the ENS actually contains more neurons than the whole of the spinal cord.

What does it do?

Its chief function is to keep things moving properly. That includes propelling food and drink along the digestive tract, which it does via a series of muscles contracting and relaxing in harmony. It ensures the contents of the intestines are well mixed, to maximize the absorption of nutrients.

In addition to aiding the movement of the digestive tract’s contents, the ENS also controls local blood flow, mucous secretions, and plays a role in the function of the immune system. It may even be connected to the development of some neurodegenerative illnesses, including Parkinson’s disease.

It is also responsible for the secretion of gastrointestinal hormones that affect the performance of organs throughout the digestive system. And it can differentiate between the nutrients needed by the body and harmful pathogens and microorganisms, allowing the former to be absorbed while keeping the latter out.

a digram showing how the microbiota and diet control the activity of multiple cell types in the gut wall,
Microbiota and diet control the activity of multiple cell types in the gut wall, including the ENS. Image: American Gastroenterological Association

Is it really the body’s second brain?

The ENS can do something most of the neural networks in the human body cannot do. It can function independently of the central nervous system – the brain and spinal cord – with which it has a network of two-way connections.

What that means is the ENS can act autonomously rather than rely on signals from the central nervous system. The ability to control gut function has earned it the nickname the ‘second brain’, although unlike the brain between your ears, the ENS has very restricted, localized control.

What has the new research found?

The latest research was led by Nick Spencer, a professor at Australia’s Flinders University. Spencer’s team studied mice using high-resolution video in combination with an analysis of electrical activity.

According to the study, published in the journal Communications Biology, how the ENS coordinates propulsion of food and drink along the gastrointestinal tract has been a “major unresolved issue”.

The paper describes how the ENS is “far more complex than expected and considerably different from the mechanisms that underlie the propulsion of fluid along other muscle organs that have evolved without an intrinsic nervous system.” Health and healthcare

How is the World Economic Forum bringing data-driven healthcare to life?

The application of “precision medicine” to save and improve lives relies on good-quality, easily-accessible data on everything from our DNA to lifestyle and environmental factors. The opposite to a one-size-fits-all healthcare system, it has vast, untapped potential to transform the treatment and prediction of rare diseases—and disease in general.

But there is no global governance framework for such data and no common data portal. This is a problem that contributes to the premature deaths of hundreds of millions of rare-disease patients worldwide.

The World Economic Forum’s Breaking Barriers to Health Data Governance initiative is focused on creating, testing and growing a framework to support effective and responsible access – across borders – to sensitive health data for the treatment and diagnosis of rare diseases.

The data will be shared via a “federated data system”: a decentralized approach that allows different institutions to access each other’s data without that data ever leaving the organization it originated from. This is done via an application programming interface and strikes a balance between simply pooling data (posing security concerns) and limiting access completely.

The project is a collaboration between entities in the UK (Genomics England), Australia (Australian Genomics Health Alliance), Canada (Genomics4RD), and the US (Intermountain Healthcare).

Among its main findings is how the thousands of neurons inside the ENS communicate with each other to help the digestive process by causing contractions in the gastrointestinal tract.

The Flinders University team’s findings also suggest that far from being the second brain, the ENS is probably much older in evolutionary terms and could even be regarded as the body’s first brain.

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