What are variants of concern, and are COVID-19 vaccines effective against them?

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This article is brought to you thanks to the collaboration of The European Sting with the World Economic Forum.

Author: Johnny Wood, Writer, Formative Content


  • The virus that causes COVID-19 is mutating constantly, and often these changes have little impact.
  • But sometimes new variants present new threats.
  • These can include being more transmissible or causing more severe symptoms.
  • The WHO is currently tracking four ‘variants of concern’.

We’ve recently been hearing virus-related terms such as mutations, variants of interest and variants of concern more and more. But what do they mean? And what can we do to protect against them?

As with other viruses, the SARS-CoV-2 that causes COVID-19 is evolving as it circulates through different parts of the world. The more opportunities a virus has to spread, the more it replicates – and this gives it more chances to mutate.

This happens because each time a virus spreads, its genome sequence – its set of genetic instructions – is copied, and often this results in tiny variations occurring. Mutations can emerge and disappear with little to no impact on the virus’s ability to cause infections and disease. But sometimes, depending where the changes are located in a virus’s genetic material, they can affect its properties.

This can lead to the virus behaving differently, for example by passing more easily from one person to another, causing more severe symptoms or reacting differently to vaccines.

What are variants of interest and variants of concern?

Variants of interest display changes that require further study, while variants of concern have demonstrated changes such as increased transmissibility or a change in clinical disease presentation.

The World Health Organization (WHO) is currently tracking transmission of four variants of concern around the world: B.1.1.7 – first identified in the UK; B.1.351 – first identified in South Africa; the P.1 variant – first identified in Japan from travellers from Brazil; and recently the B.1.617 – first identified in India.

In what is a rapidly changing situation, it’s important to stay informed about new variants. The latest information can be found on the WHO website. In this video, the organization’s Technical Lead, Dr Maria Van Kerkhove, explains more about the dominant variations currently in circulation. https://www.youtube.com/embed/_1s7__6CjtM?enablejsapi=1&wmode=transparent

What impact do variants have on vaccines?

The WHO works with health officials and scientists to understand how variants affect the virus’s behaviour – including their impact on vaccine effectiveness.

COVID-19 vaccines are expected to provide at least some protection against new variants, the organization says, because they create a broad immune response involving a range of antibodies and cells. There is evidence that vaccines are effective on some variants of concern, but more data is needed on newer variants such as B.1.617 to fully understand their implications.

Vaccine programmes are under way around the world, helping to combat the spread of COVID-19. Figures from Johns Hopkins University & Medicine show more than 1.7 billion vaccine doses have been administered worldwide.

% of population fully vaccinated.
The Seychelles has the highest number of population fully vaccinated compared to the world average. Image: Johns Hopkins University & Medicine

coronavirus, health, COVID19, pandemic

What is the World Economic Forum doing to manage emerging risks from COVID-19?

The first global pandemic in more than 100 years, COVID-19 has spread throughout the world at an unprecedented speed. At the time of writing, 4.5 million cases have been confirmed and more than 300,000 people have died due to the virus.

As countries seek to recover, some of the more long-term economic, business, environmental, societal and technological challenges and opportunities are just beginning to become visible.

To help all stakeholders – communities, governments, businesses and individuals understand the emerging risks and follow-on effects generated by the impact of the coronavirus pandemic, the World Economic Forum, in collaboration with Marsh and McLennan and Zurich Insurance Group, has launched its COVID-19 Risks Outlook: A Preliminary Mapping and its Implications – a companion for decision-makers, building on the Forum’s annual Global Risks Report.

The report reveals that the economic impact of COVID-19 is dominating companies’ risks perceptions.

Companies are invited to join the Forum’s work to help manage the identified emerging risks of COVID-19 across industries to shape a better future. Read the full COVID-19 Risks Outlook: A Preliminary Mapping and its Implications report here, and our impact story with further information.

Bodies like the WHO and the Centers for Disease Control and Prevention say we can protect ourselves and others with measures including:

  • Getting a COVID-19 vaccine when available
  • Wearing a mask covering your mouth and nose
  • Practising social distancing
  • Staying outdoors rather than inside where possible
  • Avoiding crowded places and poorly ventilated indoor spaces
  • Washing hands often.

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